Theros Beyond Death Limited is one of the only formats I can recall where the best of the best are considering including more than 40 cards in their Draft decks. Both Ben Stark and Luis Scott-Vargas have discussed this. While I haven’t ever started more than 40 cards, I have sideboarded into 45 cards on multiple occasions. Not only are there a lot of ways to churn through the library, but physical card count is a resource that matters. With five additional cards in my library, there’s simply more of that resource to dedicate to escape.
The deck I drafted in the picks below almost ran out of cards multiple times. Luckily Ashiok, Nightmare Muse kills quickly, so I didn’t need to increase the size of cards in my library because I could always scry enough cards to the bottom for protection from decking myself.
Pack 1, Pick 2
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Pack 1, Pick 4
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Pack 1, Pick 6
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